British
scientists from the Institute of Ophthalmology at University College
in London announced they may have discovered a technique to
completely cure age-related macular degeneration, or AMD, the most
common cause of blindness. The technique involves the use of
embryonic stem cells, which are transformed to resemble missing eye
cells, and inserted into the back of the retina on an artificial
membrane.
Pfizer is providing the financial backing required to transfer
the treatment from the laboratory to a usable form. Surgeons predict
that the procedure could take about one hour, and may be available
within the next six to seven years, potentially even as an
outpatient procedure.
A 2004 study from the Archives of Ophthalmology estimated that
1.75 million U.S. residents suffer from the symptoms of AMD, with a
forecast that the number would increase to 3 million by 2020, due to
longer life spans. Scientists estimate another 14 million people
suffer with the disease throughout Europe.
The AMD advancement would mark the first major proven treatment
using embryonic stem cells, and begins to address criticisms from
the religious community that adult stem cell research has generated
more practical advancements than research using embryonic stem
cells.
Why did this advancement occur in London instead of Madison?
Scientists in the United Kingdom have benefitted from a more wide
open philosophy regarding public funding of stem cell research,
using surplus embryos from in vitro fertilization. Finland, Greece
and Sweden have similar policies. In the meantime, scientists in the
United States were only able to engage in extremely limited study,
as funded by a token August 2001 decision from then-President George
W. Bush to open only existing stem cell lines for federally funded
research. Legislation was passed by both the U.S. House of
Representatives and the U.S. Senate in 2005 and 2007 to expand the
limitations on federally funded research on new stem cell lines, but
both attempts were vetoed by Bush.
Just last month, President Obama signed an executive order
removing restrictions on federal funding for new lines of embryonic
stem cells, using cells taken from discarded in vitro fertilization
treatments, for example. Human embryos still cannot be created
solely for research purposes, as limited by an amendment to the
Omnibus Appropriations Act of 2009.
Based on these policy changes, it is more likely that the next
major advancement using embryonic stem cells will originate from
within the United States, rather than Europe. But going forward, the
bioethical dilemma related to this type of science will transition
from Washington, D.C. into the waiting rooms of hospitals and
clinics around the country.
Since the artificial membrane created by the British scientists
would contain transformed embryonic stem cells, many of the millions
of people who are unable to read, recognize faces or drive a car,
might be unwilling to undergo the treatment, due to a self-imposed
bioethical and religious dilemma.
Every year, hundreds of thousands of human embryos that are left
over from in vitro fertilization treatments are eventually
destroyed, representing a monumental waste of potential positive
outcomes for millions of living, fully developed human beings.
Nobody denies that human embryos have the potential to become a
human life. But even using the broadest definition of
self-sufficiency, that potential is not realized until many months
after fertilization. A successfully implanted embryo does not
develop a heartbeat until the fifth week of pregnancy, and it doesn't
develop detectable brain activity until a month after the heart
starts beating. As many as 14 days after fertilization, an embryo
can split to form two embryos (identical twins), or two embryos can
merge to form one. Considering this state of flux from newly
fertilized eggs, it's difficult to see how such blastocysts could be
viewed as scientifically viable human lives.
For example, I have the scientific potential to win the Boston
Marathon. To make this happen, I would only require a
well-constructed bicycle to ride from the starting line to the
finish line. In other words, my potential to reach my goal is
limited by my ability to receive outside assistance. Just as I will
never win the Boston Marathon based on my own running abilities,
discarded embryos will never reach the finish line of becoming a
self-sustaining human life without a willing, living, host uterus to
facilitate their own successful completion.
Without the self-fulfilling potential to become something more,
the cells that make up a human embryo are comparable to skin cells
or any other cluster of non-viable cells. Faced to choose between
the scheduled destruction of that clump of cells, or the use of
those cells to improve the life of an elderly person who is
gradually losing their vision through AMD, the choice is obvious.
As Americans, we need to move beyond the painstakingly
manufactured religious argument against embryonic-based research and
treatments, and start to apply more common sense logic to bioethical
debates. This latest advancement serves as a good reminder that
embryonic stem cell research doesn't only exist to lure opposition
voters to the polls on election day. It now has a proven potential
to improve millions of lives.
(Tim Schilke is the author of "Growing up Red" and
lives in Grafton. His column runs Wednesdays in The Freeman.)