Mounting evidence
indicates that prostate cancer is an infectious disease caused
by a recently identified virus.
It will be some time before researchers can
definitively prove whether the virus causes prostate cancer.
And even more time to develop a successful vaccine if it does.
But the National Institutes of Health's cancer division is
impressed enough with the data to encourage researchers to
cooperate and collaborate on this topic.
Tabitha M. Powledge, a science journalist
based near Washington, D.C., says her interviews of leading
cancer experts leave her with the impression that few would be
particularly surprised to discover prostate cancer is an
infectious disease.
"There is a lot of indirect evidence
from epidemiology and genetics that prostate cancer may turn
out to be among the several cancers that are now proven
infectious," says Powledge, who specializes in writing
about basic research.
"The research does offer hope there
will be ways in the future to prevent prostate cancer just as
there are vaccines today that prevent cervical cancer."
Q. What have researchers identified as the
potential virus?
A. The suspect is xenotropic murine
leukemia-related virus, similar to viruses known to cause
cancer in animals. Researchers at Columbia University and the
University of Utah found the virus in more than a quarter of
some 300 prostate cancer tissue samples, especially in
malignant cells. Let me stress, it is not yet proven that
prostate cancer is a viral disease.
Q. Could there be more than one type of
prostate cancer?
A. Ila Singh, from the University of Utah,
senior author of that study, pointed out clinicians badly need
better tools for distinguishing between prostate cancers that
are potentially deadly and those that develop so slowly that
the affected men die of something else.
Q. Experts you interviewed have said this
virus could be sexually transmitted?
A. Yes. One bit of epidemiological evidence
is that men with a high rate of sexually transmitted diseases
tend to be more likely to get prostate cancer than men without
a strong history of STDs. Another bit of epidemiological
evidence surrounds aspirin. Researchers tell me men who take
daily aspirin to reduce inflammation for heart problems also
tend to get less prostate cancer. There is a reason, from that
result, to believe a virus may be involved because a virus
causes inflammation.
Q. If scientists can establish an infectious
cause for prostate cancer, would men potentially be able to
prevent this common deadly disease?
A. The new paper, published in the
"Proceedings of the National Academy of Sciences,"
emphasizes how finding a viral cause for prostate cancer could
impact biomedical research. It would trigger a number of
studies for vaccine and other therapies.
Q. What about the men who have prostate
cancer who do not die?
A. Researchers are looking for a marker that
will distinguish men with aggressive cancer – those in
serious health trouble – from those who don't need to do
anything.
Q. A vaccine that protects against cervical
cancer is now suggested for young women — girls not yet in
puberty — on the theory they should be immunized before they
risk getting exposed. As scientists work on studies about
whether prostate cancer is caused by a virus — and if it is,
as they develop a vaccine — what can men do?
A. Well, keep in mind that we don't know for
sure yet that prostate cancer is an infectious disease or that
it's an STD. But wearing a condom is always a sensible choice.
That's the suggestion to lower the risk of getting any
sexually transmitted disease — and there are lots of them.