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Dr.
Maria Fisher (left) works with Brenna Seeions, 8, on
weight training at Fisher and Fisher fitness and
Medical Center in Arlignton, Texas. Dr. Fisher
believes exercise and diet rather than drugs should
be used to lower cholesterol.
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FORT WORTH,
Texas - Beverly Morgan of Arlington, Texas, was 16 when she
started taking the popular cholesterol-lowering drug Vytorin.
But she
eventually abandoned the medication.
"I would
rather control my cholesterol with exercise and diet simply
because when you do put drugs in your body, you're going to
have side effects," said Morgan, 19, a student at
Mountain View Community College in Dallas. "I try to
take as little medications as possible."
While many
people share Morgan's reluctance to use drugs to lower
cholesterol, others consider the statins to be lifesavers.
Under new guidelines from the American Academy of
Pediatrics, children as young as 8 who are at high risk of
heart disease would take the medications to reduce
cholesterol. Screening should begin at age 2 and no later
than age 10 for children with a family history of heart
disease and other risks such as diabetes and high blood
pressure.
Four
prescription drugs have pediatric labeling from the Food and
Drug Administration based on clinical trials involving
children. In 2002, lovastatin became the first statin for
use in children.
NOT FOR
EVERYONE
No one is
saying every child with high cholesterol needs to be on
medications, but there are some who really do need to be
treated aggressively, said Dr. Sarah Blumenschein, a
pediatric cardiologist and associate professor at the
University of Texas Southwestern Medical Center at Dallas.
One in 300 children has a family history of high
cholesterol.
"If Dad
had a heart attack at 32, and you have an 8-year-old boy
with a cholesterol level of 300, you want that person to be
in a very safe place by the time they are 10," she
said. "Statin drugs are the way to do that."
While some
children can reduce their cholesterol levels without
medication, others simply cannot. They have high cholesterol
- sometimes 600 or more - and it has nothing to do with
exercise or what they eat, said Dr. Benjamin Siu, a
pediatric cardiologist at Cook Children's Medical Center in
Fort Worth, Texas.
A child with
an abnormal lipid profile and diabetes, hypertension or a
family history can try exercise and diet first, he said. But
by age 10 or 11 that child may need to be on medication, he
said. And he or she will need it for a lifetime.
"If you
don't treat it, you have a calculatable risk," he said.
"We do have heart attacks in young people who are in
their 20s and 30s."
RISKS AND
ALTERNATIVES
The trouble
is that the medications carry their own risks, said Dr.
Maria Fisher, an Arlington, Texas, pediatrician who runs a
fitness clinic for overweight children. As a member of the
American Academy of Pediatrics, she supports the
recommendations, but she prefers to use diet and exercise to
reduce cholesterol.
"I have
some concerns with treating kids with lipid-lowering drugs
because there is a risk of liver damage," she said.
"These are just kids, and these are adult
medications."
Children are
not static like adults, Fisher said. Their livers are
constantly changing and maturing. She also questions what
the long-term effects will be if children take the drugs
over a lifetime.
"Unfortunately,
only time will tell," she said.
The idea of
Beverly Morgan taking statins for life didn't set well with
her mother, Dorothy.
"My
feeling is to always try exercise before drugs because I
just don't trust the pharmaceuticals," Dorothy said.
"Most of these drugs are relatively new, and I was
concerned that the effect on a teenager's body would be
different."
At least
eight to 10 clinical trials have looked at statin use among
young people, and there are about 12 years of follow-up
study, Siu said.
"We know
that the statins are generally safe and do not have a
significant impact on growth and sexual maturity," he
said. "Adverse events still occur in children. However,
we have not had any irreparable liver or muscle
damage."
To reduce the
risks, children are closely monitored for liver damage and
muscle problems.
For children
at risk of heart disease, the statins offer benefits beyond
lowering cholesterol. They can also protect the lining of
the blood vessels, Blumenschein said.
"It's
like putting furniture polish on the dining room table to
protect it," she said. "The statin drugs do
exactly that."
With
one-third of children obese or overweight, there's a need to
screen for high cholesterol and address the problem early in
life, Blumenschein said. The best time to start treatment is
during childhood, when parents can still get children on a
program that in the end could save their lives. Once they
turn 18, parents have almost no control over them,
Blumenschein said.
"The
idea is early treatment to prevent these disasters that
occur at 30, 40 or 50 when they just drop over dead,"
she said.
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LIPID
SCREENING AND TREATMENT FOR HIGH CHOLESTEROL
The American
Academy of Pediatrics recommends:
-Screen
cholesterol after age 2 but no later than age 10 for
children with a family history of heart disease or other
risk factors including obesity, high blood pressure or
diabetes.
-The
best method for testing is fasting lipid profile.
-If
a child's values are normal, the test should be repeated in
three to five years.
-For
children over age 8 with high LDL concentrations,
cholesterol-reducing medications should be considered.
-Younger
patients should focus on weight reduction, increased
activity and diet.
-Children
as young as 1 year old with weight concerns should use
reduced-fat dairy products such as 2 percent milk.
Source:
American Academy of Pediatrics
Total
cholesterol levels for children ages 2-19
-Acceptable
- less than 170
-Borderline
- 170-199
-High
- 200 or greater
LDL levels
for children ages 2-19
-Acceptable
- less than 110
-Borderline
- 110-129
-High
- 130 or greater
Source:
American Heart Association