Quinn on Nutrition: What we know and donít know about artificial sweeteners

May 7, 2018

I hope Iím not the only one to find the recent news about artificial sweeteners more than just a little confusing. Hereís my snapshot on this topic:

Some sweeteners are "nutritive" meaning they provide calories. (Calories are units of energy that power our brains, muscles and the rest of our body machinery.) Sugar alcohols like sorbitol and mannitol are known as nutritive sweeteners, for example.

"Non-nutritive" (aka "artificial") sweeteners are calorie-free because our bodies do not digest them for energy. They basically pass unchanged through our digestive tracts from the mouth (where we perceive their sweet taste) to the other end. These substances are several hundreds to several thousands of times sweeter than sugar; thus these high intensity sweeteners are used in teeny tiny amounts. Acesulfame-K, aspartame, neotame, saccharin, sucralose and tagatose are non-nutritive sweeteners currently approved by the US Food and Drug Administration.

A plethora of scientific studies show that these sweetening agents are safe for humans. Some recent animal studies, however, may indicate we may not have the entire storyÖyet.

Scientists at Marquette University, for example, compared the effects of high amounts of sugar and the sweeteners aspartame and acesulfame on mice that are genetically prone to get diabetes. They found that large amounts of any of these substances increased the risks for these animals to become obese and develop diabetes.

Whatís going on? We already know that excessive amounts of sugar can make us fat and contribute to conditions like diabetes and heart disease. And sweeteners can certainly help us cut back on added sugar and excess calories.

Yet some research suggests that when we consume a sweet taste without its usual calories, the bodyís ability to regulate our appetites could be getting confused. (Perhaps that is why one person I know who will remain anonymous feels like eating M&Mís while drinking a diet Coke.)

Another area still being explored is our microbiome ó the good and bad bacteria that reside in our lower intestines. These bugs feed on what comes down the track including dietary fiber and perhaps, according to some recent studies, non-nutritive sweeteners.

When researchers at Case Western University, for example, fed large amounts of sucralose (Splenda) to rats with a gut disorder known as Crohnís disease, their symptoms got worse. The sweetener had no effect on normal mice. How then, do these undigested sweeteners affect bacteria in our human guts?

Answer: We donít know. We do know that our bodies have the machinery to handle moderate amounts of sugar and artificial sweeteners. In excess, according to one researcher from these latest studies, both may have negative effects.

Organizations like the American Diabetes Association and the American Heart Association tell us to consume sugar as well as non-nutritive sweeteners "judiciously." Iíll go with that.




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